Author

H. C. Lewis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:electronic health records· 1

Frequent Co-Authors

D. C. Avgousti· 2 shared A. D'Alessandro· 1 shared A. L. Rachubinski· 1 shared A. L. Smythers· 1 shared B. B. Flinn· 1 shared D. E. Kahn· 1 shared D. R. Kolling· 1 shared E. A. Arnold· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

D. C. Avgousti

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chemobiosis reveals tardigrade tun formation is dependent on reversible cysteine oxidation

A. L. Smythers, K. M. Joseph, H. M. O'Dell, T. A. Clark, J. R. Crislip, B. B. Flinn, M. H. Daughtridge, E. R. Stair, S. N. Mubarek, H. C. Lewis, D. R. Kolling, L. M. Hicks

This study shows that tardigrade tun formation relies on reversible cysteine oxidation driven by reactive oxygen species, using chemobiosis as a mechanism.

bioRxiv · May 15, 2023Biochemistry

HSV-1 exploits host heterochromatin for egress

H. C. Lewis, L. E. Kelnhofer-Millevolte, M. R. Brinkley, H. E. Arbach, E. A. Arnold, S. Ramachandran, D. C. Avgousti

This study shows HSV-1 uses host heterochromatin for viral egress, with loss of H3K27me3 or macroH2A1 causing capsid trapping.

bioRxiv · May 31, 2022 · PreprintMicrobiology

A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle

K. L. Lynch, M. Bat-Erdene, M. R. Dillon, H. C. Lewis, D. C. Avgousti

This study shows adenovirus protein VII disrupts the H1-HMGB balance to block the cell cycle, ensuring resources for viral replication.

bioRxiv · Dec 11, 2020Microbiology

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

R. K. Powers, K. D. Sullivan, R. Culp-Hill, M. P. Ludwig, K. P. Smith, K. A. Waugh, R. Minter, K. D. Tuttle, H. C. Lewis, A. L. Rachubinski, R. E. Granrath, R. B. Wilkerson, D. E. Kahn, M. Joshi, A. D'Alessandro, , J. M. Espinosa

This study identifies a mechanism by which Trisomy 21 increases kynurenine pathway activity through overexpression of interferon receptors, leading to immunosuppression and neurotoxicity in Down syndrome.

bioRxiv · Jan 11, 2019Physiology