R. K. Powers

A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on single motor unit discharge patterns

This paper introduces a geometric method to quantify neuromodulatory and inhibitory effects on motor unit discharge patterns using metrics like brace height and slopes, validated on simulated and human data.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

Mechanical control of innate immune responses against viral infection revealed in a human Lung Alveolus Chip

This study shows that mechanical breathing motions suppress viral replication by enhancing innate immune responses in a human Lung Alveolus Chip model.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

This study identifies a mechanism by which Trisomy 21 increases kynurenine pathway activity through overexpression of interferon receptors, leading to immunosuppression and neurotoxicity in Down syndrome.