Author

H. Chown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:fungi (other)· 3 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:genome assembly· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. Bromley· 2 shared M. C. Fisher· 2 shared T. Furukawa· 2 shared A. Mato-Lopez· 1 shared A. Morogovsky· 1 shared A. Roldan· 1 shared B. N. Celia-Sanchez· 1 shared C. G. Knight· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

M. Bromley

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Elevated mutation rates in the multi-azole resistant Aspergillus fumigatus cladedrives rapid evolution of antifungal resistance

M. J. Bottery, N. J. van Rhijn, H. Chown, J. L. Rhodes, B. N. Celia-Sanchez, M. T. Brewer, M. Momany, M. C. Fisher, C. G. Knight, M. J. Bromley

This study identifies a mutation rate increase in a multi-azole resistant Aspergillus fumigatus clade, linking it to rapid antifungal resistance evolution.

bioRxiv · Dec 5, 2023 · PreprintMicrobiology

Aspergillus fumigatus can display persistence to the fungicidal drug voriconazole

J. Scott, C. Valero, A. Mato-Lopez, I. J. Donaldson, A. Roldan, H. Chown, N. Van-Rhijn, R. Lobo-Vega, S. Gago, T. Furukawa, A. Morogovsky, R. Ben Ami, P. Bowyer, N. Osherov, T. Fontaine, , J. Amich

This study shows that some Aspergillus fumigatus isolates can persist in the presence of voriconazole, a fungicidal drug, and this persistence is associated with a distinct transcriptional profile and reduced treatment efficacy.

bioRxiv · May 16, 2022 · PreprintMicrobiology

Exploring a novel genomic safe-haven site in the human pathogenic mould Aspergillus fumigatus.

T. Furukawa, N. van Rhijn, H. Chown, J. Rhodes, N. Alfuraji, R. Fortune-Grant, E. Bignell, M. C. Fisher, M. Bromley

The paper identifies a conserved genomic safe-haven locus in Aspergillus fumigatus for inserting genetic constructs without affecting phenotype.

bioRxiv · Mar 28, 2022Microbiology