Author

M. J. Bromley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:fungi (other)· 6 Research Focus:chromatin & epigenetic regulation· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Organism:Arabidopsis· 2 Assay:DNA methylation· 2

Frequent Co-Authors

C. Valero· 4 shared N. van Rhijn· 4 shared G. H. Goldman· 3 shared P. Bowyer· 3 shared S. Gago· 3 shared A. A. Brakhage· 2 shared A. Rokas· 2 shared D. Weaver· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersMicrobiology

C. Valero

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Elevated mutation rates in the multi-azole resistant Aspergillus fumigatus cladedrives rapid evolution of antifungal resistance

M. J. Bottery, N. J. van Rhijn, H. Chown, J. L. Rhodes, B. N. Celia-Sanchez, M. T. Brewer, M. Momany, M. C. Fisher, C. G. Knight, M. J. Bromley

This study identifies a mutation rate increase in a multi-azole resistant Aspergillus fumigatus clade, linking it to rapid antifungal resistance evolution.

bioRxiv · Dec 5, 2023 · PreprintMicrobiology

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis

C. Valero, C. F. Pinzan, P. A. de Castro, N. van Rhijn, K. Earle, H. Liu, M. A. C. Horta, O. Kniemeyer, T. Krüger, A. Pschibul, D. N. Coemert, T. Heinekamp, A. A. Brakhage, J. L. Steenwyk, M. E. Mead, , G. H. Goldman

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

bioRxiv · Aug 22, 2023 · PreprintMicrobiology

The Cystic Fibrosis treatment, Trikafta, affects growth, viability, and cell wall of Aspergillus fumigatus biofilms

J. T. Jones, K. A. Morelli, E. M. Vesely, C. Puerner, C. Pavuluri, B. S. Ross, N. v. Rhijn, M. J. Bromley, R. A. Cramer

This study shows Trikafta reduces A. fumigatus biofilm biomass, viability, and metabolic activity, while increasing susceptibility to antifungal drugs.

bioRxiv · Jun 20, 2023 · PreprintMicrobiology

Mycobiome analyses of critically ill COVID-19 patients

D. Weaver, S. Gago, M. Bassetti, D. R. Giacobbe, J. Prattes, M. Hoenigl, F. Reizine, H. Guegan, J.-P. Gangneux, M. J. Bromley, P. Bowyer

This study analyzes the respiratory mycobiome of critically ill COVID-19 patients to identify fungal signatures linked to mortality and antifungal drug use.

bioRxiv · Jun 13, 2023Microbiology

COVID-19 Associated Pulmonary Aspergillosis isolates are genomically diverse but similar to each other in their responses to infection-relevant stresses

M. E. Mead, P. Alves de Castro, J. B. Steenwyk, J.-P. Gangneux, M. Hoenigl, J. Prattes, R. Rautemaa-Richardson, H. Guegan, C. B. Moore, C. Lass-Floerl, F. Reizine, C. Valero, N. van Rhijn, M. J. Bromley, A. Rokas, , S. Gago

This study analyzes 11 Aspergillus fumigatus isolates from COVID-19 patients with pulmonary aspergillosis, finding genomic diversity but similar stress responses to infection.

bioRxiv · Dec 14, 2022 · PreprintCell Biology

Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome.

A. A. Kelani, A. Bruch, F. Rivieccio, C. Visser, T. Krueger, D. Weaver, X. Pan, S. Schaeuble, G. Panagiotou, O. Kniemeyer, M. J. Bromley, P. Bowyer, A. E. Barber, A. A. Brakhage, M. G. Blango

This study investigates the role of RNA interference in Aspergillus fumigatus by analyzing genetic variation and functional outcomes of RNAi component knockouts.

bioRxiv · Jul 28, 2022Microbiology

Distinct cohorts of Aspergillus fumigatus transcription factors are required for epithelial damage occurring via contact- or soluble effector-mediated mechanisms

S. Rahman, N. van Rhijn, P. Papastamoulis, D. D. Thomson, Z. Carter, L. Gregson, R. Fortune-Grant, M. Rattray, M. J. Bromley, E. Bignell

This study identifies distinct transcription factor cohorts required for early and late phases of epithelial damage caused by Aspergillus fumigatus.

bioRxiv · Apr 7, 2022Microbiology

Every single conidium in Aspergillus fumigatus caspofungin tolerant strains are intrinsically caspofungin tolerant

C. Valero, A. C. Colabardini, P. A. de Castro, J. Amich, M. J. Bromley, G. H. Goldman

The paper investigates whether caspofungin tolerance in Aspergillus fumigatus is a population-level or individual-level trait by testing conidia from clinical isolates.

bioRxiv · Feb 17, 2022 · PreprintMicrobiology

Antagonism of the azoles to olorofim and cross-resistance are governed by linked transcriptional networks in Aspergillus fumigatus

N. van Rhijn, S. Hemmings, I. S. R. Storer, C. Valero, H. Alshammri, G. Goldman, F. Gsaller, J. Amich, M. J. Bromley

This study identifies antagonism between triazoles and olorofim in Aspergillus fumigatus due to transcriptional regulation of pyrimidine and ergosterol pathways, revealing cross-resistance mechanisms.

bioRxiv · Nov 18, 2021Microbiology

Aspergillus fumigatus ffmA encodes a C2H2-containing transcriptional regulator that modulates azole resistance and is required for normal growth

S. Paul, P. Bowyer, M. J. Bromley, W. S. Moye-Rowley

This paper identifies ffmA as a C2H2 transcription factor in Aspergillus fumigatus that modulates azole resistance and normal growth through interactions with AtrR and regulation of AbcG1 expression.

bioRxiv · Nov 17, 2021 · PreprintMicrobiology