Author

H. J. Newton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

N. E. Scott· 2 shared A. Hachani· 1 shared A. S. Hayes· 1 shared B. P. Howden· 1 shared C. A. Khoo· 1 shared C. C. Oppy· 1 shared C. J. Walsh· 1 shared C. Oates· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

N. E. Scott

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Author profile →

3 papers

Recent·Most cited

A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

A. Hachani, S. G. Giulieri, R. Guerillot, C. J. Walsh, M. Herisse, Y. M. Soe, S. L. Baines, D. R. Thomas, S. D. Cheung, A. S. Hayes, H.-J. Cho, H. J. Newton, S. Pidot, R. C. Massey, B. P. Howden, T. P. Stinear

The paper develops a high-throughput platform to identify S. aureus mutations that enhance intracellular persistence and reduce cytotoxicity, revealing agr-independent pathoadaptive mutations.

bioRxiv · Dec 11, 2022Microbiology

Proteomic identification of Coxiella burnetii effector proteins targeted to the host cell mitochondria during infection

L. F. Fielden, N. E. Scott, C. S. Palmer, C. A. Khoo, H. J. Newton, D. Stojanovski

This study identifies four novel mitochondrially-targeted effector proteins from Coxiella burnetii using proteomics and organelle purification during native infection.

bioRxiv · May 28, 2020Cell Biology

Loss of O-linked protein glycosylation in Burkholderia cenocepacia impairs biofilm formation and siderophore production via alteration of quorum sensing regulation

C. C. Oppy, L. Jebeli, M. Kuba, C. Oates, R. A. Strugnell, L. Edgington-Mitchell, M. A. Valvano, E. L. Hartland, H. J. Newton, N. E. Scott

This paper shows that loss of O-linked glycosylation in B. cenocepacia disrupts quorum sensing, leading to reduced biofilm formation and siderophore production.

bioRxiv · Sep 4, 2019 · PreprintMicrobiology