Author

S. L. Baines

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 3 Research Focus:host-pathogen & immune response· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

T. P. Stinear· 5 shared B. P. Howden· 3 shared G. P. Carter· 3 shared A. Hachani· 2 shared C. J. Walsh· 2 shared R. C. Massey· 2 shared R. Guerillot· 2 shared S. J. Pidot· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersMicrobiology

T. P. Stinear

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

O. Xie, J. M. Morris, A. J. Hayes, R. J. Towers, M. G. Jespersen, J. A. Lees, N. L. Ben Zakour, O. Berking, S. L. Baines, G. P. Carter, G. Tonkin-Hill, L. Schrieber, L. McIntyre, J. L. Lacey, T. B. James, , M. R. Davies

The paper shows extensive genomic overlap between Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis, including shared genes and recombination events, with implications for vaccine development.

bioRxiv · Aug 10, 2023Microbiology

The two-component regulator WalKR provides an essential link between cell wall homeostasis with DNA replication in Staphylococcus aureus

L. K. R. Sharkey, R. Guerillot, C. J. Walsh, A. M. Turner, J. Y. H. Lee, S. L. Neville, S. Klatt, S. L. Baines, S. J. Pidot, F. J. Rossello, T. Seeman, H. McWilliam, E. Cho, G. P. Carter, B. P. Howden, , I. R. Monk

This study identifies the WalKR two-component system in Staphylococcus aureus as a polyfunctional regulator linking cell wall homeostasis with DNA replication and other essential processes.

bioRxiv · Feb 27, 2023 · PreprintMicrobiology

A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

A. Hachani, S. G. Giulieri, R. Guerillot, C. J. Walsh, M. Herisse, Y. M. Soe, S. L. Baines, D. R. Thomas, S. D. Cheung, A. S. Hayes, H.-J. Cho, H. J. Newton, S. Pidot, R. C. Massey, B. P. Howden, T. P. Stinear

The paper develops a high-throughput platform to identify S. aureus mutations that enhance intracellular persistence and reduce cytotoxicity, revealing agr-independent pathoadaptive mutations.

bioRxiv · Dec 11, 2022Microbiology

Significant Variability exists in the Toxicity of Global Methicillin-resistant Staphylococcus aureus Lineages.

M. Laabei, S. Peacock, B. Blane, S. L. Baines, T. P. Stinear, B. Howden, R. C. Massey

The paper assesses toxicity variability among global MRSA lineages and identifies Agr mutations linked to reduced toxicity, highlighting the role of undefined genes in toxin regulation.

bioRxiv · Jul 16, 2021Microbiology

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae

M. Hennart, L. G. Panunzi, C. Rodrigues, Q. Gaday, S. L. Baines, M. Barros-Pinkelnig, A. Carmi-Leroy, M. Dazas, A.-M. Wehenkel, X. Didelot, J. Toubiana, E. Badell, S. Brisse

This study investigates antimicrobial resistance in Corynebacterium diphtheriae by analyzing genomic and phenotypic data from 247 strains, identifying resistance mechanisms and plasmids.

Genome Medicine · Nov 27, 2020Peer-reviewedMicrobiology

Vaccine-specific immune responses against Mycobacterium ulcerans infection in a low-dose murine challenge model

K. M. Mangas, A. H. Buultjens, J. L. Porter, S. L. Baines, E. Marion, L. Marsollier, N. J. Tobias, S. J. Pidot, K. M. Quinn, D. J. Price, K. Kedzierska, W. Zeng, D. C. Jackson, B. Y. Chua, T. P. Stinear

This study evaluates a prime-boost vaccine against Mycobacterium ulcerans in mice, finding that both the experimental ER vaccine and BCG provide significant protection through distinct immune profiles.

bioRxiv · Oct 10, 2019Immunology

Remodelling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in Methicillin-Resistant Staphylococcus aureus

S. L. Baines, S. O. Jensen, N. Firth, A. Goncalves da Silva, T. Seemann, G. P. Carter, D. A. Williamson, B. P. Howden, T. P. Stinear

This study examines the evolution of pSK1 family plasmids in MRSA ST239 isolates over 32 years, showing their role in enhancing chlorhexidine tolerance and gentamicin resistance.

bioRxiv · Oct 31, 2018Evolutionary Biology