Author

H. L. Mead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Organism:C. elegans· 2 Research Focus:differential expression· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. M. Barker· 6 shared P. Keim· 4 shared A. Li· 2 shared D. R. Kollath· 2 shared H. D. Bean· 2 shared J. Yu· 2 shared J. Zhang· 2 shared M. Caligiuri· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersMicrobiology

B. M. Barker

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6 papers

Recent·Most cited

Volatile metabolites in lavage fluid are correlated to Valley fever disease severity in murine model lung infections

E. A. H. Keppler, M. C. C. Van Dyke, H. L. Mead, D. F. Lake, D. M. Magee, B. M. Barker, H. D. Bean

This study identifies volatile metabolites in murine lung infections correlated with Valley fever disease severity, suggesting potential breath-based diagnostic biomarkers.

bioRxiv · Oct 2, 2022 · PreprintMicrobiology

FXa cleaves the SARS-CoV-2 spike protein and blocks cell entry to protect against infection with inferior effects in B.1.1.7 variant

J. Yu, W. Dong, J. Wang, L. Tian, J. Zhang, H. L. Mead, S. Jaramillo, A. Li, R. Zumwalt, S. P. J. Whelan, E. Settles, P. Keim, B. M. Barker, M. Caligiuri

This study shows FXa cleaves SARS-CoV-2 spike protein, blocking viral entry, but B.1.1.7 variant is resistant, and FXa inhibitors like rivaroxaban reduce this protection.

bioRxiv · Jun 7, 2021 · PreprintMicrobiology

The K18-hACE2 Transgenic Mouse Model Recapitulates Non-Severe and Severe COVID-19 in Response to Infectious Dose of SARS-CoV-2 Virus

J. Yu, W. Dong, A. Li, J. Zhang, M. Caligiuri, S. Jaramillo, H. L. Mead, N. E. Stone, A. Jones, D. R. Kollath, V. K. Coyne, M. Yearsley, L.-S. Wang, B. M. Barker, P. Keim, T. Barr

The paper characterizes the K18-hACE2 mouse model's response to different SARS-CoV-2 doses, showing dose-dependent disease severity and recovery, and compares it to human COVID-19 pathology.

bioRxiv · May 8, 2021Microbiology

The Effect of Minnelide against SARS-CoV-2 in a Murine Model

M. C. Caballero Van Dyke, H. L. Mead, M. Bryant, K. L. Laux, D. R. Kollath, V. K. Coyne, K. J. Miller, N. E. Stone, S. A. Jaramillo, P. Keim, C. Milikowski, V. K. Gupta, S. M. Vickers, A. Saluja, M. R. Velagapudi, B. M. Barker

This study evaluates Minnelide's efficacy in treating SARS-CoV-2 infection in mice, showing reduced viral load, improved survival, and decreased inflammation.

bioRxiv · May 5, 2021 · PreprintMicrobiology

Lifecycle dominates the volatilome character of the dimorphic fungus Coccidioides spp.

E. A. Higgins Keppler, H. L. Mead, B. M. Barker, H. D. Bean

This study characterizes the volatile metabolomes of Coccidioides species during different growth phases, finding that lifecycle, not species, drives the volatilome profile, suggesting a unified biomarker approach for Valley fever detection.

bioRxiv · Jan 15, 2021Microbiology

Differential thermotolerance adaptation between species of Coccidioides

H. L. Mead, P. S. Hamm, I. N. Shaffer, M. de Melo Teixeira, C. Wendel, N. P. Wiederhold, G. R. Thompson, R. Muniz-Salazar, L. R. Castanon-Olivares, P. Keim, C. Plude, J. Terriquez, J. N. Galgiani, M. J. Orbach, B. M. Barker

This study compares thermotolerance between two Coccidioides species by measuring growth rates at different temperatures, finding C. posadasii grows faster at 37°C than C. immitis.

bioRxiv · Aug 12, 2020Microbiology