Author

H. Luksch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Roesen-Wolff· 2 shared R. Behrendt· 2 shared A. Ablasser· 1 shared A. Gerbaulet· 1 shared A. Linkermann· 1 shared A. Loff· 1 shared A. M. C. Boehner· 1 shared A. Roers· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

A. Roesen-Wolff

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

H. Luksch, F. Schulze, D. Geissler-Lösch, D. Sprott, L. Höfs, E. M. Szegö, W. Tonnus, S. Winkler, C. Günther, A. Linkermann, R. Behrendt, L. L. Teichmann, B. H. Falkenburger, A. Rösen-Wolff

This study shows that constitutive STING activation in mice causes SAVI, and TNF signaling mediates its pathogenesis, with TNFR1/2 inhibition improving disease symptoms.

bioRxiv · Apr 25, 2024Immunology

Clearance of genome-damaged cells from the hematopoietic system via p53 without contribution by the cGAS/STING axis

N. Dressel, L. Natusch, C. Munz, S. Costas-Ramon, M. N. F. Morcos, A. Loff, B. Hiller, H. Luksch, A. Roesen-Wolff, A. Roers, R. Behrendt, A. Gerbaulet

This study shows that p53 clears genome-damaged hematopoietic cells without needing the cGAS/STING pathway, and that cGAS/STING is not required for coping with DNA damage or preventing leukemia in RER-deficient conditions.

bioRxiv · Jun 24, 2022 · PreprintCell Biology

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

N. Kessler, S. F. Viehmann, C. Krollmann, K. Mai, K. M. Kirschner, H. Luksch, P. Kotagiri, A. M. C. Boehner, D. Huugen, C. C. de Oliveira Mann, S. Otten, S. A. I. Weiss, T. Zillinger, K. Dobrikova, D. E. Jenne, , N. Garbi

This study identifies cGAS/STING/IFN-mediated nucleic acid sensing by monocyte-derived macrophages as a driver of severe pulmonary vasculitis and shows that targeting this pathway reduces disease severity.

bioRxiv · May 30, 2022Immunology