Author

T. Zillinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Assay:bulk RNA-seq· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

G. Hartmann· 5 shared E. Bartok· 3 shared K. Paeschke· 2 shared M. Schlee· 2 shared A. A. Hyman· 1 shared A. Ablasser· 1 shared A. Buness· 1 shared A. Chhabra· 1 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersImmunology

G. Hartmann

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

RIG-I activation primes and trains innate antiviral immune memory

M. S. Adamson, S. Nesic, A. Buness, K. Bayrak, S. Schmitz, S. Soler, T. Zillinger, S. Marx, S. Lambing, K. Andryka-Cegielski, F. Khan, T. M. Schlee-Guimaraes, S. Herberhold, M. Proietti, K. Placek, , E. Bartok

RIG-I activation primes and trains innate immune responses, enhancing non-specific antiviral protection in immune and non-immune cells.

bioRxiv · Oct 27, 2022 · PreprintImmunology

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

A. K. de Regt, K. Anand, K. Ciupka, K. Gatterdam, B. Putschli, D. Fusshoeller, D. Hilbig, A. Kirchhoff, C. Hunkler, S. Wolter, A. Gruenewald, C. Schuberth-Wagner, J. Ludwig, K. Paeschke, E. Bartok, , M. Schlee

This study identifies an isoleucine residue in RIG-I that prevents recognition of 5p-RNA, thereby maintaining immune tolerance to mitochondrial RNA.

bioRxiv · Aug 2, 2022Immunology

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

S. Maharana, S. Kretschmer, S. Hunger, X. Yan, D. Kuster, S. Traikov, T. Zillinger, N. Chappidi, N. Lucas, K. I. Maser, H. Maatz, A. Rapp, V. Marchand, V. Iyer, A. Chhabra, , M. A. Lee-Kirsch

This study shows SAMHD1 regulates innate immunity by controlling RNA condensation, preventing immune recognition of self RNA and reducing inflammation.

bioRxiv · Jul 12, 2022Immunology

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

N. Kessler, S. F. Viehmann, C. Krollmann, K. Mai, K. M. Kirschner, H. Luksch, P. Kotagiri, A. M. C. Boehner, D. Huugen, C. C. de Oliveira Mann, S. Otten, S. A. I. Weiss, T. Zillinger, K. Dobrikova, D. E. Jenne, , N. Garbi

This study identifies cGAS/STING/IFN-mediated nucleic acid sensing by monocyte-derived macrophages as a driver of severe pulmonary vasculitis and shows that targeting this pathway reduces disease severity.

bioRxiv · May 30, 2022Immunology

cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA

T. Schumann, S. C. Ramon, N. Schubert, M. A. Mayo, M. Hega, S.-R. Ada, L. Sydow, M. Hajikazemi, Y. Ge, M. Badstübner, S. Lienenklaus, B. Utess, L. Muhandes, M. Haase, L. Müller, , R. Behrendt

The paper shows that loss of SAMHD1 leads to chronic DNA damage and cGAS/STING-dependent type I interferon production in mice, linking it to autoimmunity and cancer.

bioRxiv · May 16, 2022Immunology

Human IFITM3 restricts Chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction

S. Franz, T. Zillinger, F. Pott, C. Schüler, S. Dapa, C. Fischer, V. Passos, S. Stenzel, F. Chen, K. Döhner, G. Hartmann, B. Sodeik, F. Pessler, G. Simmons, J. F. Drexler, C. Goffinet

This study shows IFITM3 restricts CHIKV and MAYV infection and is counteracted by these viruses, with a variant showing similar antiviral activity to wild-type.

bioRxiv · Sep 11, 2020Microbiology