Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
S. Watanuki, H. Kobayashi, Y. Sugiura, M. Yamamoto, D. Karigane, K. Shiroshita, Y. Sorimachi, S. Fujita, T. Morikawa, S. Koide, M. Oshima, A. Nishiyama, K. Murakami, H. Miho, S. Tamaki, , K. Takubo
This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.
bioRxiv · Mar 16, 2023Cell Biology