S. Fujita

Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysis

This study shows that cold temperatures reduce zebrafish swimming activity and increase muscle atrophy genes, but forced swimming at low temperatures reduces these genes, suggesting exercise can prevent muscle atrophy.

Comparisons of two receptor pathways in a single cell-type reveal features of signalling specificity.

The paper compares two receptor pathways in Arabidopsis root endodermis cells, showing distinct outputs despite similar MPK phosphorylation patterns, suggesting specificity through combinatorial activation and cross-pathway inhibition.

Determination of the factors responsible for host tropism of SARS-CoV-2-related bat coronaviruses

The paper identifies specific residues in the spike protein and ACE2 receptor that determine the host tropism of two SARS-CoV-2-related bat coronaviruses.

Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis

This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.

ORF3c is expressed in SARS-CoV-2 infected cells and suppresses immune activation by inhibiting innate sensing

This study identifies ORF3c as an immune evasion factor of SARS-CoV-2 that suppresses innate sensing by inhibiting RIG-I and MDA5 signaling.

Enhanced transmissibility, infectivity and immune resistance of the SARS-CoV-2 Omicron XBB.1.5 variant

This study evaluates the transmissibility, infectivity, and immune resistance of the SARS-CoV-2 Omicron XBB.1.5 variant, finding it more transmissible and resistant than previous variants.

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

Spring growth variation in pioneer and fibrous roots in Abies sachalinensis seedlings from provenances with contrasting snow cover environments

This study examines intraspecific variation in root growth dynamics of Abies sachalinensis seedlings from contrasting snow cover provenances, finding differences in morphological and structural traits of pioneer and fibrous roots.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

Sensitivity of novel SARS-CoV-2 Omicron subvariants, BA.2.11, BA.2.12.1, BA.4 and BA.5 to therapeutic monoclonal antibodies

This study evaluates the sensitivity of new Omicron subvariants to eight therapeutic monoclonal antibodies, finding increased resistance in BA.4/5 to cilgavimab compared to BA.2.

A peptide-mediated, multilateral molecular dialogue for the coordination of pollen wall formation

The paper reveals a multilateral molecular dialogue involving three cell types that coordinates pollen wall formation through peptide signaling and subtilase activity.

Microtubule-based perception of mechanical conflicts controls plant organ morphogenesis

The paper shows that microtubule asymmetry in Arabidopsis thaliana endodermis is required for lateral root formation and morphogenesis.

Combined fluorescent seed selection and multiplex CRISPR/Cas9 assembly for fast generation of multiple Arabidopsis mutants

The paper develops a CRISPR/Cas9 toolbox for generating multiple Arabidopsis mutants using fluorescent seed selection and multiplex gRNA introduction.

Schengen-pathway controls spatially separated and chemically distinct lignin deposition in the endodermis.

The paper shows that endodermal lignin sensing triggers a transcriptional reprogramming leading to chemically distinct compensatory lignin deposition and impacts nutrient homeostasis.

High-order mutants reveal an essential requirement for peroxidases but not laccases in Casparian strip lignification

This study identifies peroxidases as essential for Casparian strip lignification in Arabidopsis, while laccases are not required for this process.

ROS production by localized SCHENGEN receptor module drives lignification at subcellular precision

The paper identifies a kinase signaling relay that controls ROS production and lignification with subcellular precision by leveraging kinase localization and ROS as a co-substrate.

A two-way molecular dialogue between embryo and endosperm required for seed development

The paper identifies a bidirectional molecular dialogue between embryo and endosperm involving TWS1 and ALE1 to ensure cuticle integrity during seed development.

Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.

This paper identifies the molecular mechanism by which plant receptor kinases GSO1/SGN3 and GSO2 recognize sequence-divergent CIF peptides through structural and biochemical analyses.