Author

S. Sridharan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

M. M. Savitski· 3 shared A. A. Hyman· 2 shared I. Poser· 2 shared X. Zhang· 2 shared A. C. Murthy· 1 shared A. Hermann· 1 shared A. J. Baldwin· 1 shared A. Kotecha· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

M. M. Savitski

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Author profile →

6 papers

Recent·Most cited

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

H. Uechi, S. Sridharan, J. Nijssen, J. Bilstein, J. M. Iglesias-Artola, S. Kishigami, V. Casablancas-Antras, I. Poser, E. J. Martinez, E. Boczek, M. Wagner, N. Tomschke, A. M. de Jesus Domingues, A. Pal, T. Doeleman, , R. J. Wheeler

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

bioRxiv · Jan 5, 2024 · PreprintCell Biology

Rules for hardening influenza A virus liquid condensates

T. A. Etibor, S. Vale-Costa, S. Sridharan, D. Bras, I. Becher, V. H. Mello, F. Ferreira, M. Alenquer, M. M. Savitski, M. J. Amorim

This study demonstrates that modulating transient interactions in influenza A virus condensates is more effective for hardening than temperature or concentration changes, offering a strategy for antiviral drug design.

bioRxiv · Aug 3, 2022Cell Biology

BMAL1 and MEX3A co-regulate intestinal stem cell succession

F.-P. Chang, C.-K. Wang, Y.-C. Chou, T.-J. Chen, Y.-W. Wu, S. Sridharan, P.-H. Hsu, W. W. Hwang-Verslues

This study identifies BMAL1 and MEX3A as regulators of intestinal stem cell succession and shows that timing chemotherapy can protect stem cells by modulating their circadian expression.

bioRxiv · Mar 8, 2022 · PreprintCell Biology

Molecular mechanisms of stress-induced reactivation in mumps virus condensates

X. Zhang, S. Sridharan, I. Zagoriy, C. Eugster Oegema, C. Ching, T. Pflaesterer, H. K. H. Fung, I. Poser, C. W. Mueller, A. A. Hyman, M. M. Savitski, J. Mahamid

The paper investigates how cellular stress triggers reactivation of persistent mumps virus infection through molecular and structural changes in viral condensates.

bioRxiv · Jul 10, 2021Cell Biology

Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs

D. M. Kern, B. Sorum, S. S. Mali, C. M. Hoel, S. Sridharan, J. P. Remis, D. B. Toso, A. Kotecha, D. M. Bautista, S. G. Brohawn

This study presents the cryo-EM structure of SARS-CoV-2 3a ion channel in lipid nanodiscs, revealing its functional properties and evolutionary conservation.

Nature Structural & Molecular Biology · Jun 22, 2021Peer-reviewedBiophysics

Simultaneous cell traction and growth measurements using light

S. Sridharan, Y. Li, L. Foucard, H. Majeed, B. Bhaduri, A. Levine, K. Kilian, G. Popescu

This paper introduces a method to simultaneously measure cell traction forces and growth using light-based imaging, showing that mesenchymal stem cells exert different forces during osteogenesis and adipogenesis.

bioRxiv · Oct 20, 2017Cell Biology