Author

J. Nijssen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. A. Hyman· 2 shared N. L. Fawzi· 2 shared S. Alberti· 2 shared A. C. Murthy· 1 shared A. Hermann· 1 shared A. Honigmann· 1 shared A. J. Baldwin· 1 shared A. M. de Jesus Domingues· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

A. A. Hyman

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Author profile →

3 papers

Recent·Most cited

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

X. Yan, D. Kuster, P. Mohanty, J. Nijssen, K. Pombo-Garcia, A. Rizuan, T. M. Franzmann, A. Sergeeva, P. M. dos Passos, L. George, S.-H. Wang, J. Shenoy, H. L. Danielson, A. Honigmann, Y. M. Ayala, , A. A. Hyman

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

bioRxiv · Jan 23, 2024Cell Biology

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

H. Uechi, S. Sridharan, J. Nijssen, J. Bilstein, J. M. Iglesias-Artola, S. Kishigami, V. Casablancas-Antras, I. Poser, E. J. Martinez, E. Boczek, M. Wagner, N. Tomschke, A. M. de Jesus Domingues, A. Pal, T. Doeleman, , R. J. Wheeler

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

bioRxiv · Jan 5, 2024 · PreprintCell Biology

Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.

J. C. Correia, Y. Kelahmetoglu, P. R. Jannig, C. Schweingruber, D. Svaikovskaya, L. Zhengye, I. Cervenka, M. Oliveira, J. Nijssen, V. Martinez-Redondo, M. Stec, N. Khan, J. T. Lanner, S. Kleiner, E. Hedlund, J. L. Ruas

This paper shows that muscle-secreted neurturin (NRTN) couples muscle oxidative metabolism with slow motor neuron identity, improving exercise performance and motor coordination.

bioRxiv · Mar 31, 2021Physiology