R. J. Wheeler

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

3D electron microscopy of the Leishmania mexicana cell cycle: Patterns of organelle duplication and segregation and their implications for parasite biology

This study uses 3D electron microscopy to analyze Leishmania mexicana cell cycle stages, revealing organelle duplication, segregation patterns, and metabolic adaptations in different environments.

Divergent Protein Kinase A contributes to the regulation of flagellar waveforms in Leishmania mexicana

This study investigates the role of divergent PKA isoforms in regulating flagellar waveforms in Leishmania mexicana, showing their impact on swimming speed and waveform patterns.

Identification of 30 transition fibre proteins reveals a complex and dynamic structure with essential roles in ciliogenesis

The paper identifies 30 new transition fibre proteins in Trypanosoma brucei and shows their dynamic roles in ciliogenesis and flagellum length regulation.

Subcellular protein localisation of Trypanosoma brucei bloodstream form-upregulated proteins maps stage-specific adaptations

The paper maps subcellular localisation of bloodstream form-upregulated proteins in Trypanosoma brucei, revealing stage-specific organelle associations.

Genome-wide subcellular protein localisation in the flagellate parasite Trypanosoma brucei

The paper maps subcellular protein localization in Trypanosoma brucei using fluorescence microscopy, revealing functional insights and organelle adaptations.

A resource for improved predictions of Trypanosoma and Leishmania protein three-dimensional structure

The paper improves protein structure predictions for Trypanosoma and Leishmania by enhancing sequence data and providing tools for AlphaFold2 predictions.

Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activator

The paper identifies ESB1 as a stage-specific activator required for monoallelic VSG transcription in Trypanosoma brucei, revealing its role in Pol I recruitment to the expression site body.

Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections

This study identifies flagellar proteins in Leishmania and shows that directional motility is essential for parasite colonization of sand flies.