J. W. Brown

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.

A new role for IFRD1 in regulation of ER stress in bladder epithelial homeostasis

This study identifies IFRD1 as a key regulator of ER stress and urothelial homeostasis in mice, showing its role in maintaining bladder function and preventing cell shedding.

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolopyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2

The paper develops analogs of SGC-CK2-1 to improve pharmacokinetic properties in mice by inhibiting GST and P450 enzymes through co-dosing protocols.

REVEILLE2 Thermosensitive Splicing: A Molecular Basis for the Integration of Nocturnal Temperature Information by the Arabidopsis Circadian Clock

This study identifies a temperature-sensitive splicing switch in the REVEILLE2 gene that integrates nocturnal temperature changes with the circadian clock in Arabidopsis.

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

The paper shows that inhibiting the kinase CSNK2 blocks replication of several beta-coronaviruses, including SARS-CoV-2, by preventing viral entry.

BaRTv2: A highly resolved barley reference transcriptome for accurate transcript-specific RNA-seq quantification

The paper develops BaRTv2.18, a highly resolved barley reference transcriptome, improving transcript diversity and quantification accuracy over previous versions.

A high resolution single molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis

This paper introduces a new Arabidopsis transcriptome dataset with improved accuracy and resolution using novel Iso-seq analysis methods, enhancing transcript expression and splicing analysis.

3'-Sulfated Lewis A is a Biomarker for Metaplastic and Oncogenic Transformation of Several Gastrointestinal Epithelia

This study identifies 3-Sulfo-Lewis A as the epitope recognized by the antibody Das-1, which is reexpressed in metaplastic and carcinomatous gastrointestinal lesions.

Evolution of Portulacineae marked by gene tree conflict and gene family expansion associated with adaptation to harsh environments

This study reconstructs the phylogeny of Portulacineae and examines molecular evolution correlates with adaptation to harsh environments, identifying gene duplications and expansions linked to stress responses.

The choice of tree prior and molecular clock does not substantially affect phylogenetic inferences of diversification rates

This study evaluates how tree priors and molecular clocks affect diversification rate estimates in Bayesian phylogenetics, finding minimal impact when data are informative and substitution rates are low-to-moderate.

Analyzing contentious relationships and outlier genes in phylogenomics

The paper identifies outlier genes causing conflict between supermatrix and coalescent-based species trees in two datasets and proposes a framework for examining alternative edges in phylogenomic analyses.

So many genes, so little time: a practical approach to divergence-time estimation in the genomic era

The paper introduces a method to improve divergence-time estimation by filtering genes from phylogenomic datasets based on clock-likeness and topological compatibility, showing it reduces error in time inference.

The Past Sure Is Tense: On Interpreting Phylogenetic Divergence Time Estimates

The paper investigates how prior assumptions in divergence time estimation can lead to inaccurate age estimates for angiosperms, even without data, highlighting issues with calibration densities and prior distributions.

Quartet Sampling distinguishes lack of support from conflicting support in the plant tree of life

The paper introduces Quartet Sampling (QS), a method to distinguish conflicting support from poor support in plant phylogenies, showing it effectively identifies discordant evolutionary relationships.

Disparity, Diversity, And Duplications In The Caryophyllales

The paper maps whole genome duplications (WGDs) and diversification shifts in Caryophyllales, finding some correlations but no tight link between WGDs and diversification rates.

Bayesian and likelihood phylogenetic reconstructions of morphological traits are not discordant when taking uncertainty into consideration. A comment on Puttick et al.

The paper critiques Puttick et al.'s conclusion that Bayesian methods are superior for phylogenetic reconstruction from morphological traits, arguing that their comparison was flawed and that ML and Bayesian methods are concordant when uncertainty is properly considered.