Author

H.-M. Shen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

B. W. L. Tan· 1 shared B. W. Q. Tan· 1 shared C. Chai· 1 shared C. Liu· 1 shared C. Y. Ng· 1 shared E. Wong· 1 shared G. Lu· 1 shared H. W.-S. Tan· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

B. W. L. Tan

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

mTOR S-nitrosylation inhibits autophagy and lysosomal proteolysis

B. W. Q. Tan, S. Tan, B. W. L. Tan, S. Navakkode, C. Y. Ng, S. Yuan, M. C. Liang, C. Liu, S. Yin, C. Chai, K. C. M. Chew, Y. K. Tai, S. Sreedharan, Y. Lam, P. Liao, , T. W. Soong

This study identifies mTOR S-nitrosylation as a kinase-independent mechanism that suppresses autophagy and lysosomal proteolysis, with implications for Alzheimer's disease.

bioRxiv · Sep 11, 2020 · PreprintCell Biology

Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition

Y. Ren, J. Chen, X. Mo, Q. Yang, P. Chen, G. Lu, H. W.-S. Tan, J. Yi, Q. Yu, Y.-S. Kim, K. Mallilankaraman, H.-M. Shen

This study identifies glucose starvation and SGLT2 inhibition as synthetic lethal strategies for EGFR-WT/LKB1-mutant NSCLC, showing efficacy in xenograft models.

bioRxiv · Apr 29, 2019 · PreprintCancer Biology