Author

H.-Y. Shih

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Physiology· 1

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

J. Gopalakrishnan· 2 shared A. Behensky· 1 shared A. I. Lim· 1 shared A. McCurdy· 1 shared A. Santoni· 1 shared A. Scheer· 1 shared A. Sharpe· 1 shared A. Stacy· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

J. Gopalakrishnan

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Author profile →

5 papers

Recent·Most cited

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

R. A. Stephenson, K. R. Johnson, L. Cheng, L. G. Yang, J. T. Root, J. Gopalakrishnan, H.-Y. Shih, P. S. Narayan

This study shows that triglyceride metabolism is essential for microglial activation and disease states in APOE4 microglia, with implications for modulating immune responses.

bioRxiv · Apr 11, 2024Cell Biology

Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss

N. Fernando, J. Gopalakrishnan, A. Behensky, L. Reich, C. Liu, V. Bass, M. Bono, W. Montgomery, R. De Pace, M. Mattapallil, V. Nagarajan, S. Brooks, D. Maric, R. Caspi, D. McGavern, H.-Y. Shih

This study identifies a unique CD8+ T cell population in AD mouse brains that contributes to amyloid beta-associated memory loss and shows that reducing these cells improves memory and reduces plaque formation.

bioRxiv · Mar 18, 2023 · PreprintImmunology

Maternal infection promotes offspring tissue-specific immune fitness

A. I. Lim, T. McFadden, V. Link, S.-J. Han, R.-M. Karlsson, A. Stacy, T. K. Farley, O. J. Harrison, H.-Y. Shih, H. A. Cameron, Y. Belkaid

Maternal infection during pregnancy leads to tissue-specific immune changes in offspring through IL-6-induced epigenetic modifications in intestinal epithelial cells.

bioRxiv · Jan 13, 2021 · PreprintImmunology

When killers become thieves: trogocytosed PD-1 inhibits NK cells in cancer

M. S. Hasim, M. Marotel, J. J. Hodgins, E. Vulpis, H.-Y. Shih, A. Scheer, O. MacMillan, F. Alonso, K. Burke, D. P. Cook, M. T. Petrucci, A. Santoni, P. Fallon, A. Sharpe, G. Sciume, , M. Ardolino

Natural Killer cells acquire PD-1 from tumor cells via trogocytosis, which inhibits anti-tumor immunity.

bioRxiv · Jun 26, 2020Immunology

Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

M. Keefe, H. Soderholm, H.-Y. Shih, T. Stevenson, K. Glaittli, D. M. Bowles, E. Scholl, S. Colby, S. Merchant, E. Hsu, J. Bonkowsky

This study shows that truncated EIF2B5 expression in zebrafish models of VWM activates the ISR and impairs motor behavior, suggesting a feed-forward mechanism in disease pathophysiology.

bioRxiv · May 5, 2020Physiology