Author

J. Gopalakrishnan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Assay:organoid / primary culture· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

A. Mariappan· 2 shared A. Ramani· 2 shared E. Gabriel· 2 shared H.-Y. Shih· 2 shared K. Hadian· 2 shared L. Ricci-Vitiani· 2 shared O. Goureau· 2 shared R. Pallini· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCell Biology

A. Mariappan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

R. A. Stephenson, K. R. Johnson, L. Cheng, L. G. Yang, J. T. Root, J. Gopalakrishnan, H.-Y. Shih, P. S. Narayan

This study shows that triglyceride metabolism is essential for microglial activation and disease states in APOE4 microglia, with implications for modulating immune responses.

bioRxiv · Apr 11, 2024Cell Biology

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion, and drug screening

A. Ramani, G. Pasquini, N. Gerkau, O. S. Vinchure, E. Gabriel, I. Rothenaigner, S. Lin, N. Altinisk, D. Rathinam, A. Mirsaidi, O. Goureau, L. Ricci-Vitiani, G. Q. d'alessandris, R. Pallini, B. Wollnik, , J. Gopalakrishnan

This study develops a high-throughput method to generate reliable human brain organoids for modeling microcephaly, glioma invasion, and drug screening.

bioRxiv · Oct 29, 2023Cell Biology

Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory loss

N. Fernando, J. Gopalakrishnan, A. Behensky, L. Reich, C. Liu, V. Bass, M. Bono, W. Montgomery, R. De Pace, M. Mattapallil, V. Nagarajan, S. Brooks, D. Maric, R. Caspi, D. McGavern, H.-Y. Shih

This study identifies a unique CD8+ T cell population in AD mouse brains that contributes to amyloid beta-associated memory loss and shows that reducing these cells improves memory and reduces plaque formation.

bioRxiv · Mar 18, 2023 · PreprintImmunology

Cilium induction triggers differentiation of glioma stem cells

G. Goranci-Buzhala, A. Mariappan, L. Ricci-Vitiani, N. Josipovic, S. Pacion, M. Gottardo, J. Ptok, G. C. Callaini, K. Rajalingam, B. Dynlacht, K. Hadian, A. Papantonis, R. Pallini, J. Gopalakrishnan

This study shows that inducing ciliogenesis in glioma stem cells (GSCs) promotes their differentiation and prevents brain infiltration, suggesting cilium induction as a therapeutic strategy for glioblastoma.

bioRxiv · Dec 23, 2020Cell Biology

SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects

J. Gopalakrishnan, A. Ramani, L. Mueller, P. Niklas Ostermann, E. Gabriel, A. Islam Pranty, A. Mueller-Shiffmann, A. Mariappan, O. Goureau, H. Gruell, A. Walker, M. Andree, S. Hauka, K. Wohlgemuth, H. Omran, , A. Dilthey

This study shows SARS-CoV-2 infects cortical neurons in 3D human brain organoids, causing neurodegeneration-like effects such as Tau mislocalization and neuronal death.

bioRxiv · May 20, 2020Cell Biology