D. P. Cook

Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancer

The paper compares syngeneic mouse models of high-grade serous ovarian cancer to identify differences in signaling, metabolic, and functional properties, as well as tumor microenvironment variability.

Novel Apelin-expressing gCap Endothelial Stem-like Cells Orchestrate Lung Microvascular Repair

This study identifies novel apelin-expressing gCap endothelial stem-like cells that drive lung microvascular repair after endothelial cell ablation by apelin signaling.

Single-cell RNA sequencing-based characterization of resident lung mesenchymal stromal cells in bronchopulmonary dysplasia

This study uses scRNA-seq to characterize resident lung mesenchymal stromal cells in normal development and BPD, finding hyperoxia alters their gene expression and identifies Serpinf1 as a stable marker.

Transcriptional census of epithelial-mesenchymal plasticity in cancer

The paper identifies expression patterns of epithelial-mesenchymal plasticity in 160 tumors across 8 cancer types using scRNA-seq and links these patterns to regulatory mechanisms in the tumor microenvironment.

Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation

This study shows PREX1 links PI 3-kinase signaling to Lgl1 phosphorylation in glioblastoma, while TIAM1 can also promote Lgl1 phosphorylation in some patients.

When killers become thieves: trogocytosed PD-1 inhibits NK cells in cancer

Natural Killer cells acquire PD-1 from tumor cells via trogocytosis, which inhibits anti-tumor immunity.

Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

This study investigates stemness traits in ovarian surface epithelium and finds that stemness is context-specific and not consistently linked to specific signaling pathways or a single population.

Cre-mediated deletion of SMARCA5 disrupts pluripotency in mouse embryonic stem cells

This study shows that deleting Snf2h in mouse ESCs disrupts pluripotency by altering key markers and genome-wide nucleosome distribution.

Multiplexed single-cell transcriptomic analysis of normal and impaired lung development in the mouse

The paper uses scRNA-seq to analyze lung development in mice under normal and hyperoxic conditions, identifying cellular changes linked to bronchopulmonary dysplasia.

Comparing transcriptional dynamics of the epithelial-mesenchymal transition

This study compares the transcriptional dynamics of the epithelial-mesenchymal transition across multiple contexts, identifying conserved genes and transcription factors involved in the process.