Nephron segmentation and patterning in kidney organoids can be modulated by distinct FGF subfamily members
Allara K. Zylberberg, Emma I. Scully, Pei Xuan Er, Hannah Baric, Michelle Scurr, Mian Xie, Thanushi Peiris, Sara E. Howden, Kynan T. Lawlor, Melissa Helen Little
This study shows that distinct FGF subfamily members modulate nephron patterning in kidney organoids, with FGF8b and FGF10 having unique effects on proximal and distal nephron development.
bioRxiv · Jun 10, 2025 · PreprintDevelopmental Biology