Attenuated interferon signalling in alveolar epithelium limits resistance to Streptococcus pyogenes
Jeremy Wiyana, Declan L. Turner, Sahel Amoozadeh, Pooja Venkat, Katelyn Patatsos, Hannah R. C. Frost, Joshua Osowicki, Jasmyn Voss, Kaneka Chheng, Kristy I. Azzopardi, Natalie Caltabiano, Mark R. Davies, Mirana Ramialison, Catherine Satzke, Fernando Jaime Rossello, , Rhiannon B. Werder
This study compares S. pyogenes infection responses in airway and alveolar epithelial cells, finding that alveolar cells show higher cell death and a pro-inflammatory response without cytokine secretion, and that IFN-β treatment reduces infection.
bioRxiv · Apr 15, 2026 · PreprintMicrobiology