Sara E. Howden

This study uses iPSC-derived muscle models to show that DUX4 base editing improves muscle function in childhood-onset FSHD.

This study classifies off-target and indeterminate cell types in human kidney organoid differentiation using single-cell transcriptomics.

This study demonstrates the use of prime editing to efficiently introduce heterozygous mutations in human pluripotent stem cells with high knock-in efficiency and without purification or selection steps.

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

This study shows that distinct FGF subfamily members modulate nephron patterning in kidney organoids, with FGF8b and FGF10 having unique effects on proximal and distal nephron development.

DevKidCC classifies kidney organoid cell subtypes accurately by comparing datasets to a reference model trained on human fetal kidney single-cell RNA-seq data.

The paper demonstrates the use of bioprinted kidney organoids for high content drug screening, showing reproducibility and response to doxorubicin toxicity.