Robert C. Brewster

E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism

The paper shows that E. coli transcription factors regulate promoter activity through a universal homeostatic mechanism by stabilizing RNA polymerase in a context-dependent manner.

Regulatory properties of transcription factors with diverse mechanistic function

This study models how transcription factors regulate gene expression by altering transcription steps, revealing how promoter strength and TF mechanisms affect steady-state regulation, noise, and response time.

Probing the dependence of transcription factor regulatory modes on promoter features

The paper investigates how transcription factor regulatory modes depend on promoter features by using synthetic promoters in E. coli to uncover TF-specific principles.

Controlling gene expression timing through gene regulatory architecture

The paper investigates how gene regulatory architecture influences gene expression timing and response fidelity through stochastic simulations of single-input module motifs.

Tunable Transcription Factor Library for Robust Quantification of Gene Expression Dynamics in E. coli

The paper introduces a tunable TF library in E. coli to study TF concentration effects on gene regulation, showing distinct roles for ZntR and GalR/GalS.

Quantifying the regulatory role of individual transcription factors in Escherichia coli

The paper quantifies how individual transcription factors regulate gene expression in E. coli by isolating their effects using synthetic genes and a thermodynamic model.

Flexibility and constraint in preimplantation gene regulation in mouse

The paper examines how different fertilization methods affect preimplantation gene regulation in mouse embryos, identifying stable and flexible gene expression patterns and the role of sperm RNAs in development.

Regulatory asymmetry in the negative single-input module network motif: Role of network size, growth rate and binding affinity

The paper investigates regulatory asymmetry in a negatively regulated single-input module (SIM) network, finding that the TF gene experiences stronger repression than its targets despite identical regulatory DNA.

A Persistence Detector for Metabolic Network Rewiring in an Animal

The paper identifies a persistence detector in an animal that redirects propionate breakdown to a shunt pathway when flux through the canonical pathway is perturbed.