Md Zulfikar Ali

The paper shows that E. coli transcription factors regulate promoter activity through a universal homeostatic mechanism by stabilizing RNA polymerase in a context-dependent manner.

This study models how transcription factors regulate gene expression by altering transcription steps, revealing how promoter strength and TF mechanisms affect steady-state regulation, noise, and response time.

The paper investigates how gene regulatory architecture influences gene expression timing and response fidelity through stochastic simulations of single-input module motifs.

The paper introduces a tunable TF library in E. coli to study TF concentration effects on gene regulation, showing distinct roles for ZntR and GalR/GalS.

The paper investigates regulatory asymmetry in a negatively regulated single-input module (SIM) network, finding that the TF gene experiences stronger repression than its targets despite identical regulatory DNA.

The paper identifies a persistence detector in an animal that redirects propionate breakdown to a shunt pathway when flux through the canonical pathway is perturbed.