Sunil Guharajan

The paper introduces dubTAGs, small molecules that stabilize proteins tagged with FKBP12F36V by recruiting deubiquitinases, enabling tunable and reversible control of protein levels.

The paper shows that E. coli transcription factors regulate promoter activity through a universal homeostatic mechanism by stabilizing RNA polymerase in a context-dependent manner.

This study models how transcription factors regulate gene expression by altering transcription steps, revealing how promoter strength and TF mechanisms affect steady-state regulation, noise, and response time.

The paper investigates how transcription factor regulatory modes depend on promoter features by using synthetic promoters in E. coli to uncover TF-specific principles.

The paper quantifies how individual transcription factors regulate gene expression in E. coli by isolating their effects using synthetic genes and a thermodynamic model.