TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia
Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L. Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael Cahalan
This study shows that TREM2 loss in human iPSC-derived microglia leads to altered Ca2+ signaling and motility via purinergic receptor pathways.
eLife · Feb 22, 2022Peer-reviewedNeuroscience