Ethosuximide: subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels
Boris Shalomov, Theres Friesacher, Daniel Yakubovich, John Carlo Combista, Haritha P. Reddy, Shoham Dabbah, Harald Bernsteiner, Eva‐Maria Zangerl‐Plessl, Anna Stary‐Weinzinger, Nathan Dascal
This study identifies ethosuximide as a subunit-selective, Gβγ-dependent blocker of GIRK channels, revealing its mechanism of action and potential as a therapeutic tool.
British Journal of Pharmacology · Jan 15, 2025Peer-reviewedPharmacology & Toxicology