Author

William Charles Spanos

Sanford ResearchORCID 0000-0002-7975-1151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Canchai YangiD· 2 shared Craig C. WelboniD· 2 shared Dohun PyeoniD· 2 shared Lexi VuiD· 2 shared M. I. KhaliliD· 2 shared Abigail Z. BennettiD· 1 shared Andrew J. OliveiD· 1 shared C. YiniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Canchai YangORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ULK1 drives NDP52-mediated selective autophagic degradation of MHC-I to promote immune evasion in HPV-positive head and neck cancer

Lexi Vu, Nicholas S. Giacobbi, M. I. Khalil, Canchai Yang, Will Eckerman, Evelyn Gomez Recinos, Johnathon D. Garber, Hyomin Son, Prerna Chahal, Dara M Villa, Tasha Srivastava, Abigail Z. Bennett, Katie R. Martin, Craig C. Welbon, Caitlin S. Williamson, , Dohun Pyeon

This study identifies ULK1-driven autophagy as a mechanism by which HPV+ HNC cells degrade MHC-I, promoting immune evasion and tumor growth.

bioRxiv · Mar 18, 2026 · PreprintCancer Biology

The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins

M. I. Khalil, Jie Wang, Lexi Vu, Canchai Yang, C. Yin, Smriti Chadha, Harrison Nabors, Daniel B. Vocelle, Danielle G. May, Rachel J. Chrisopulos, Craig C. Welbon, Li Zhou, Kyle J. Roux, William Charles Spanos, Matthew P. Bernard, , Dohun Pyeon

This study identifies MARCHF8 as a driver of cancer immune evasion by degrading MHC-I proteins and shows its inhibition enhances antitumor immunity and response to immunotherapy.

Proceedings of the National Academy of Sciences · Mar 9, 2026Peer-reviewedCancer Biology