Author

Heidi J. Elsaesser

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

David G. BrooksiD· 3 shared Diala Abd-RabboiD· 3 shared Fauzia N. Izzati· 2 shared Landon J. EdgariD· 2 shared Tracy L. McGahaiD· 2 shared Wenxi Xu· 2 shared Aled Blundell· 1 shared Arthur MorthaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersImmunology

David G. BrooksORCID

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3 papers

Recent·Most cited

Sequential infection reprograms the immune landscape to shape future responses

Mengdi Guo, Yanis Hichem Bouzaher, Diala Abd-Rabbo, Rene Quevedo, Heidi J. Elsaesser, Wenxi Xu, Melissa Liu, Fauzia N. Izzati, Teresa Ciudad, Matthew Bianca, Kitty Liu, Joao Oliveira, Arthur Mortha, Landon J. Edgar, Tracy L. McGaha, , David G. Brooks

This study shows that sequential infections in mice remodel immune landscapes, making them more similar to human immunity and affecting future immune responses.

bioRxiv · Jul 1, 2026 · PreprintImmunology

Functional Type I and Type II interferon crosstalk restricts progenitor exhausted CD8 T cells through spatial exclusion and checkpoint enforcement

S. Liu, Heidi J. Elsaesser, René Vielman Quevedo, Diala Abd-Rabbo, Bruna C. Bertol, Wenxi Xu, Melissa Yi Ran Liu, Sabelo Lukhele, Sara Lamorte, Tracy L. McGaha, David G. Brooks

This study identifies a spatially encoded interferon circuit that restricts progenitor exhausted CD8 T cells during chronic infection by enforcing niche sequestration and checkpoint control.

bioRxiv · Mar 3, 2026 · PreprintImmunology

A Unified Atlas of T cell Glycophysiology

Fauzia N. Izzati, Hani Choksi, Paolo Giuliana, Diala Abd-Rabbo, Heidi J. Elsaesser, Aled Blundell, Vanessa Affe, Vinicius Kannen, Zeinab Jame-Chenarboo, Edward N. Schmidt, Meggie Kuypers, David B. Avila, Eric S. Y. Chiu, Dzhangar Badmaev, Haissi Cui, , Landon J. Edgar

This study characterizes T cell glycosylation patterns across mouse and human tissues, revealing species-specific differences in glycan profiles and dynamics.

Cell Reports · Jul 1, 2025Peer-reviewedImmunology