Author

Wenxi Xu

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

David G. BrooksiD· 3 shared Diala Abd-RabboiD· 2 shared Heidi J. Elsaesser· 2 shared Tracy L. McGahaiD· 2 shared Arthur MorthaiD· 1 shared Blair R. G. GordoniD· 1 shared Bruna C. BertoliD· 1 shared Dustin SokolowskiiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

David G. BrooksORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

High Dimensional Immune Profiling Reveals CD39 as a Correlate of Tuberculosis Disease Severity

Jacqueline Watt, Dustin Sokolowski, Wenxi Xu, Ying Quan, Kyle Burrows, Jason Galutira, Blair R. G. Gordon, David G. Brooks, Jun Liu

This study uses high-dimensional immune profiling to identify CD39 as a correlate of tuberculosis disease severity and shows its potential as a therapeutic target.

bioRxiv · Jul 7, 2026 · PreprintImmunology

Sequential infection reprograms the immune landscape to shape future responses

Mengdi Guo, Yanis Hichem Bouzaher, Diala Abd-Rabbo, Rene Quevedo, Heidi J. Elsaesser, Wenxi Xu, Melissa Liu, Fauzia N. Izzati, Teresa Ciudad, Matthew Bianca, Kitty Liu, Joao Oliveira, Arthur Mortha, Landon J. Edgar, Tracy L. McGaha, , David G. Brooks

This study shows that sequential infections in mice remodel immune landscapes, making them more similar to human immunity and affecting future immune responses.

bioRxiv · Jul 1, 2026 · PreprintImmunology

Functional Type I and Type II interferon crosstalk restricts progenitor exhausted CD8 T cells through spatial exclusion and checkpoint enforcement

S. Liu, Heidi J. Elsaesser, René Vielman Quevedo, Diala Abd-Rabbo, Bruna C. Bertol, Wenxi Xu, Melissa Yi Ran Liu, Sabelo Lukhele, Sara Lamorte, Tracy L. McGaha, David G. Brooks

This study identifies a spatially encoded interferon circuit that restricts progenitor exhausted CD8 T cells during chronic infection by enforcing niche sequestration and checkpoint control.

bioRxiv · Mar 3, 2026 · PreprintImmunology