Heidrun von Thien

A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

The paper introduces a new computational pipeline for var gene expression analysis, showing changes in var gene expression and core transcriptome during in vitro culture of Plasmodium falciparum.

PMRT1, a Plasmodium specific parasite plasma membrane transporter is essential for asexual and sexual blood stage development

The paper investigates six membrane transporters in Plasmodium falciparum, finding four essential for asexual development and one essential for gametocytogenesis.

Characterization of apicomplexan amino acid transporters (ApiATs) in the malaria parasite Plasmodium falciparum

This study characterizes ApiATs in Plasmodium falciparum, showing their localization to the parasite plasma membrane and partial redundancy in asexual proliferation but not gametocytogenesis.

Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severecases

The paper identifies PfEMP1 variants associated with severe malaria in first-time infected adults and non-severe cases using RNA-seq and var gene analysis.