Aubrey J. Cunnington

Histone lactylation: a new epigenetic mark in the malaria parasite Plasmodium

The paper identifies histone lactylation as a new epigenetic mark in malaria parasites, showing its metabolic sensitivity and differential abundance between species.

A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia

The paper identifies a 5-transcript signature in blood samples that distinguishes bacterial from viral pneumonia with high accuracy.

Anemia and tissue hypoxia are major determinants of malarial hypelactatemia

This study investigates the role of anemia and tissue hypoxia in hyperlactatemia during severe malaria using a murine model and human samples.

A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

The paper introduces a new computational pipeline for var gene expression analysis, showing changes in var gene expression and core transcriptome during in vitro culture of Plasmodium falciparum.

Electricity-free nucleic acid extraction method from dried blood spots on filter paper for point-of-care diagnostics

The paper develops an electricity-free nucleic acid extraction method from dried blood spots on filter paper for point-of-care diagnostics, showing comparable performance to standard methods.

Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria

This study compares transcriptomic profiles between human malaria patients and mouse models to identify which models best reflect human disease features.

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

This study uses dual transcriptome analysis to identify host and parasite gene expression associated with severe malaria in Gambian children, showing parasite load explains most human gene expression differences but only a third of parasite gene differences.

Estimating parasite load dynamics to reveal novel resistance mechanisms to human malaria

The paper estimates parasite load dynamics in malaria to identify host resistance mechanisms, finding novel roles for proteases and detrimental effects of interferon response.