Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance
Paul V. Heinrich, Raina M. Jung, Jonathan Samuel Achter, Vincent X. Nguyen, Carissa Lee, Carolin Sailer, Henna Domian, Alison Schroer Vander Roest, Fabian Patrik Suchy, James W.S. Jahng, Ana Kojic, Daniel Lee, A Paasche, Brock Roberts, Hiromitsu Nakauchi, , Sean M. Wu
This study investigates factors influencing HCM phenotype penetrance by comparing MYH7 mutations in isogenic hiPSC-CMs and shows that beta-adrenergic stimulation and gene dosage affect disease expression.
bioRxiv · Jun 6, 2026 · PreprintMolecular Biology