Genome-scale mapping of DNA damage suppressors identifies GNB1L as essential for ATM and ATR biogenesis
Yichao Zhao, Daniel R. Tabet, Diana Rubio-Contreras, Arne Nedergaard Kousholt, Jochen Weile, Henrique Melo, Lisa Hoeg, Atina G. Coté, Zhen‐Yuan Lin, Dheva Setiaputra, Jos Jonkers, Anne‐Claude Gingras, Fernando Gómez-Herreros, Frederick P. Roth, Daniel Durocher
The paper identifies 160 genes that suppress DNA damage in human cells through CRISPR/Cas9 screens, highlighting GNB1L's role in ATR biogenesis and its link to neuropsychiatric disorders.
bioRxiv · Sep 23, 2022 · PreprintMolecular Biology