Dheva Setiaputra

The paper identifies DDIAS as a DNA-binding effector of the CIP2A-TOPBP1 complex that suppresses single-stranded DNA during mitosis, protecting genome integrity and interacting genetically with DNA polymerase.

The paper identifies PACT as a key inhibitor of PKR during viral infection and shows that PACT and ADAR1 cooperate to prevent aberrant PKR activation by self-dsRNAs.

The paper identifies NFATC2IP as a mediator of SUMO-dependent genome integrity through CRISPR/Cas9 screens and functional validation.

The paper uses AlphaFold2 to predict structural interactions in the 53BP1 pathway, identifying a novel RIF1-SHLD3 binding interface critical for DNA repair.

The paper identifies 160 genes that suppress DNA damage in human cells through CRISPR/Cas9 screens, highlighting GNB1L's role in ATR biogenesis and its link to neuropsychiatric disorders.

This study identifies RIF1 as a phosphopeptide-binding protein that interacts with phosphorylated 53BP1 epitopes to facilitate DNA repair and modulate shieldin recruitment.