Author

Fernando Gómez-Herreros

Instituto de Biomedicina de SevillaORCID 0000-0002-5693-3489Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Diana Rubio-ContrerasiD· 2 shared Anne‐Claude GingrasiD· 1 shared Arne Nedergaard KousholtiD· 1 shared Atina G. CotéiD· 1 shared Binghui SheniD· 1 shared Carmen Angulo-Jiménez· 1 shared Carmen Jordán-Pérez· 1 shared Daniel Delgado‐BellidoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenetics

Diana Rubio-ContrerasORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

EXO1 Facilitates MiDAS and Prevents Genome Instability and Cell Death in Ewing Sarcoma

Joaquín Olmedo-Pelayo, Laura Lobo-Selma, Daniel Delgado‐Bellido, Carmen Jordán-Pérez, Paula Gilabert-Prieto, Marco Pérez, Florian H. Geyer, Martha Julia Carreño-Gonzalez, Javier Alonso, Li Zheng, Binghui Shen, Thomas G. P. Grünewald, Fernando Gómez-Herreros, Enrique de Álava

This study identifies EXO1 as essential for Ewing sarcoma cell survival and shows its role in preventing genome instability and cell death by facilitating MiDAS.

bioRxiv · Jun 9, 2026 · PreprintCancer Biology

SCAN1 mutant TDP1 blocks the repair of DSB induced by TOP1 activity during gene transcription and promotes genome reorganisations and cell death in quiescent cells

Diana Rubio-Contreras, Daniel Hidalgo-García, Carmen Angulo-Jiménez, Esperanza Granado-Calle, Margarita Sabio-Bonilla, José F. Ruiz, Fernando Gómez-Herreros

This study shows that the SCAN1 mutation H493R in TDP1 blocks repair of TOP1-induced DSBs in quiescent cells, leading to genome instability and cell death.

Cell Death and Disease · Nov 28, 2025Peer-reviewedGenetics

Genome-scale mapping of DNA damage suppressors identifies GNB1L as essential for ATM and ATR biogenesis

Yichao Zhao, Daniel R. Tabet, Diana Rubio-Contreras, Arne Nedergaard Kousholt, Jochen Weile, Henrique Melo, Lisa Hoeg, Atina G. Coté, Zhen‐Yuan Lin, Dheva Setiaputra, Jos Jonkers, Anne‐Claude Gingras, Fernando Gómez-Herreros, Frederick P. Roth, Daniel Durocher

The paper identifies 160 genes that suppress DNA damage in human cells through CRISPR/Cas9 screens, highlighting GNB1L's role in ATR biogenesis and its link to neuropsychiatric disorders.

bioRxiv · Sep 23, 2022 · PreprintMolecular Biology