Author

Christi A. Silva

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Arthur M. MercurioiD· 3 shared Boris S. Dimitrov· 2 shared Hira Lal Goel· 2 shared Anastasia KhvorovaiD· 1 shared Ashley SummersiD· 1 shared Ayush KumariD· 1 shared Christopher D Dahlke· 1 shared Claire E. TochenyiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Arthur M. MercurioORCID

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3 papers

Recent·Most cited

Activation of a STAT3/LATS1 Signaling Axis by Folate Receptor α Enables Breast Cancer Cells to Resist Physiological Ferroptotic Stress

Prajakta Prasad Ambegaokar, Hira Lal Goel, Emmet R. Karner, Boris S. Dimitrov, Christi A. Silva, Arthur M. Mercurio

This study identifies a STAT3/LATS1 signaling axis mediated by folate receptor α that enables breast cancer cells to resist ferroptotic stress from ECM detachment and IKE treatment.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

Folate Receptor α Contributes to Radiation Resistance in Neuroendocrine Prostate Cancer by Regulating Redox Homeostasis

Hira Lal Goel, Tao Wang, Boris S. Dimitrov, Ayush Kumar, Christi A. Silva, Thomas J. FitzGerald, Arthur M. Mercurio

This study identifies folate receptor α as a key contributor to radiation resistance in neuroendocrine prostate cancer by maintaining redox homeostasis through the folate-FR axis.

bioRxiv · Mar 30, 2026 · PreprintCancer Biology

Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth

Claire E. Tocheny, Julianna E. Buchwald, Christopher D Dahlke, Hassan H. Fakih, Jennifer S. Morgan, Ashley Summers, Christi A. Silva, Samuel O. Jackson, Ji-Sun Lee, Michael-Anthony Card, Dimas Echeverria, Cornelia Peterson, Arthur M. Mercurio, Anastasia Khvorova, Leslie M. Shaw

This study delivers IRS2-targeting siRNAs to mammary tumors via albumin-binding dendrimers, reducing tumor growth by inhibiting Irs2 expression and altering tumor microenvironment features.

Molecular Therapy · Jan 29, 2026Peer-reviewedCancer Biology