Author

Jennifer S. Morgan

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ji-Sun LeeiD· 2 shared Leslie M. ShawiD· 2 shared Michael-Anthony CardiD· 2 shared Quyen Thu BuiiD· 2 shared Anastasia KhvorovaiD· 1 shared Arminja Nadine KettenbachiD· 1 shared Arthur M. MercurioiD· 1 shared Ashley SummersiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCell Biology

Ji-Sun LeeORCID

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Author profile →

3 papers

Recent·Most cited

Insulin receptor substrate 2 (IRS2) confers resistance to PI3K pathway inhibition in PIK3CA mutant breast cancer

Michael W. Lero, Jennifer S. Morgan, Michael-Anthony Card, Lihua Julie Zhu, Junhui Li, Rui Li, Quyen Thu Bui, Emma Mohlmann, Hira Lal Goel, Leslie M. J. Shaw

This study identifies IRS2 as a mediator of resistance to PI3K pathway inhibitors in PIK3CA mutant breast cancer by sustaining PI3K signaling through FOXO3-mediated regulation.

Journal of Biological Chemistry · Aug 10, 2026Peer-reviewedCancer Biology

Interaction of IRS2 with PLK1 protects cells from mitotic stress

Ji-Sun Lee, Quyen Thu Bui, Minjeong Jo, Jennifer S. Morgan, Isha Nasa, Arminja Nadine Kettenbach, Leslie M. Shaw

This study identifies IRS2's role in protecting cells from mitotic stress through its interaction with PLK1, distinct from its signaling function.

Cell Death and Disease · Apr 8, 2026Peer-reviewedCell Biology

Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth

Claire E. Tocheny, Julianna E. Buchwald, Christopher D Dahlke, Hassan H. Fakih, Jennifer S. Morgan, Ashley Summers, Christi A. Silva, Samuel O. Jackson, Ji-Sun Lee, Michael-Anthony Card, Dimas Echeverria, Cornelia Peterson, Arthur M. Mercurio, Anastasia Khvorova, Leslie M. Shaw

This study delivers IRS2-targeting siRNAs to mammary tumors via albumin-binding dendrimers, reducing tumor growth by inhibiting Irs2 expression and altering tumor microenvironment features.

Molecular Therapy · Jan 29, 2026Peer-reviewedCancer Biology