Author

Holly Kane

Denali Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Allisa J. Clemens· 2 shared Arash MoshkforoushiD· 2 shared Darren Chan· 2 shared David A. JoyiD· 2 shared Elysia Roche· 2 shared Jason C. DugasiD· 2 shared Johann ChowiD· 2 shared Joseph N. DuqueiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Allisa J. Clemens

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2 papers

Recent·Most cited

Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules

Robert C. Wells, Padma Akkapeddi, Darren Chan, David A. Joy, Arash Moshkforoush, Roni Chau, Johann Chow, Gerald Maxwell Cherf, Ellen Y. T. Chien, Allisa J. Clemens, Michelle E. Pizzo, Ahlam N. Qerqez, Tiffany M. Tran, Isabel A. Becerra, Jason C. Dugas, , Kylie S. Chew

This paper demonstrates that dual targeting of TfR and CD98hc enhances brain exposure of large molecules compared to single-target approaches.

Cell Reports · Jul 22, 2025Peer-reviewedNeuroscience

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution compared to standard antibodies

Nathalie Khoury, Michelle E. Pizzo, Claire B. Discenza, David A. Joy, David Tatarakis, Mihail Ivilinov Todorov, Moritz Negwer, Connie Ha, Gabrielly Lunkes de Melo, Lily Sarrafha, Matthew J. Simon, Darren Chan, Roni Chau, Kylie S. Chew, Johann Chow, , Y. Joy Yu Zuchero

This study compares the biodistribution of Fc-engineered molecules targeting BBB receptors with standard antibodies, showing distinct CNS and peripheral organ targeting.

bioRxiv · Jul 11, 2024 · PreprintNeuroscience