J. W. Lee

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

Mature microRNA-binding protein QKI promotes microRNA-mediated gene silencing

The paper identifies QKI as a novel microRNA-binding protein that enhances AGO2/let-7b-mediated gene silencing and suppresses tumor growth.

Metabolic engineering of Saccharomyces cerevisiae for second-generation ethanol production from xylo-oligosaccharides and acetate

This study engineers Saccharomyces cerevisiae to simultaneously ferment xylo-oligosaccharides, xylose, and acetate, producing 60% more ethanol and 12% less xylitol than the control strain.

Targeted Eicosanoid Profiling Reveals MicroRNA-155 Shifts PGE2/PGD2 Balance Towards Oncogenic State

This study shows miR-155 shifts PGE2/PGD2 balance towards an oncogenic state by regulating enzymes involved in prostaglandin synthesis.

Differential TM4SF5-mediated SIRT1 modulation and signaling for chronic liver disease

This study identifies TM4SF5's role in modulating SIRT1 and STAT3 signaling during NAFL to NASH progression, showing age-dependent effects and potential therapeutic targets.

Trajectories from Snapshots: Integrated proteomic and metabolic single-cell assays reveal multiple independent adaptive responses to drug tolerance in a BRAF-mutant melanoma cell line

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

Changes in the expression of mitochondrial morphology-related genes during the differentiation of murine embryonic stem cells

The paper examines mitochondrial morphology-related gene expression during murine ESC differentiation and proposes an index based on Mfn2/Dnm1L ratio to reflect mitochondrial changes.

Transcriptomes of major renal collecting-duct cell types in mouse identified by single-cell RNA-Seq

The paper identifies transcriptomes of major renal collecting-duct cell types in mice using single-cell RNA-Seq and creates an online gene-expression database.