Author

I. Poudyal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:structural biology· 3 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

S. Pandey· 5 shared M. Schmidt· 4 shared T. N. Malla· 4 shared D. Feliz· 3 shared M. Noda· 3 shared A. Barty· 2 shared E. Stojkovic· 2 shared G. Calvey· 2 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersBiophysics

S. Pandey

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Vitamin C Binds to SARS Coronavirus-2 Main Protease Essential for Viral Replication

T. N. Malla, S. Pandey, L. Aldama, D. Feliz, M. Noda, I. Poudyal, G. N. Phillips, E. A. Stojkovic, M. Schmidt

This study reports the crystal structure of SARS-CoV-2 main protease bound to Vitamin C, showing its potential as an inhibitor of viral replication.

bioRxiv · May 2, 2021 · PreprintBiophysics

Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

S. Pandey, G. Calvey, A. M. Katz, T. N. Malla, F. Koua, J. Martin-Garcia, I. Poudyal, J.-H. Yang, M. Vakili, O. Yefanov, K. A. Zielinski, S. Bajt, S. Awel, K. Doerner, M. Frank, , M. Schmidt

The paper directly observes fast ligand binding in a biomedically relevant enzyme using MHz X-ray pulses at the European XFEL.

bioRxiv · Nov 24, 2020 · PreprintBiophysics

High-resolution Crystal Structures of Transient Intermediates in the Phytochrome Photocycle

M. Carrillo, S. Pandey, J. Sanchez, M. Noda, I. Poudyal, L. Aldama, T. N. Malla, E. Claesson, W. Yuan Wahlgreen, D. Feliz, V. Srajer, M. Maj, L. Castillon, S. Iwata, E. Nango, , M. Schmidt

The paper captures high-resolution crystal structures of transient phytochrome intermediates to elucidate the structural changes during the Pr-to-Pfr photocycle.

bioRxiv · Sep 16, 2020Biophysics

Ebselen Reacts with SARS Coronavirus-2 Main Protease Crystals

T. N. Malla, S. Pandey, I. Poudyal, D. Feliz, M. Noda, G. Phillips, E. Stojkovic, M. Schmidt

This paper shows that Ebselen inhibits SARS-CoV-2 main protease 3CLpro by destroying its crystal diffraction power, suggesting it as a potential antiviral agent.

bioRxiv · Aug 10, 2020 · PreprintBiophysics

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

J. Olmos, S. Pandey, J. M. Martin-Garcia, G. Calvey, A. Katz, J. Knoska, C. Kupitz, M. S. Hunter, M. Liang, D. Oberthuer, O. Yefanov, M. Wiedorn, M. Heymann, M. Holl, K. Pande, , Our

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

bioRxiv · Jan 18, 2018Biophysics