Author

I. R. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

J. A. Paulo· 4 shared B. A. Schulman· 3 shared J. C. Paoli· 3 shared J. W. Harper· 3 shared A. Bieber· 2 shared C. Capitanio· 2 shared F. Kraus· 2 shared F. Wilfling· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCell Biology

J. A. Paulo

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Author profile →

4 papers

Recent·Most cited

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

F. Kraus, Y. He, S. Swarup, K. A. Overmyer, J. Brenner, C. Capitanio, A. Bieber, A. Jen, N. M. Nightingale, B. J. Anderson, C. Lee, J. A. Paulo, I. R. Smith, J. M. Plitzko, S. P. Gygi, , J. W. Harper

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

bioRxiv · Mar 26, 2024Cell Biology

Combinatorial selective ER-phagy remodels the ER during neurogenesis

M. J. Hoyer, C. Capitanio, I. R. Smith, J. C. Paoli, A. Bieber, Y. Jiang, J. A. Paulo, M. A. Gonzalez-Lozano, W. Baumeister, F. Wilfling, B. A. Schulman, W. Harper

The paper quantifies ER proteome remodeling during neurogenesis using ER-phagy receptors and identifies receptor-specific ER protein clearance mechanisms.

bioRxiv · Jun 26, 2023Cell Biology

Quantitative mapping of autophagic cargo during nutrient stress reveals YIPF3-YIPF4 as membrane receptors for Golgiphagy

K. L. Hickey, S. Swarup, I. R. Smith, J. C. Paoli, J. A. Paulo, J. W. Harper

The paper identifies YIPF3 and YIPF4 as membrane receptors for Golgiphagy during nutrient stress and shows their role in autophagic degradation of Golgi proteins.

bioRxiv · Dec 6, 2022Cell Biology

PARK15/FBXO7 is dispensable for PINK1/Parkin-dependent mitophagy in iNeuron and HeLa cell systems

F. Kraus, E. A. Goodall, I. R. Smith, Y. Jiang, J. C. Paoli, F. Adolf, J. Zhang, J. A. Paulo, B. A. Schulman, J. W. Harper

This study shows FBXO7 is not required for PINK1/Parkin-dependent mitophagy in HeLa and iNeuron cells, as its absence does not impair key mitophagy processes.

bioRxiv · Nov 2, 2022Cell Biology