F. Wilfling

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

Autophagy preferentially degrades non-fibrillar polyQ aggregates

This study shows autophagosomes preferentially degrade non-fibrillar polyQ aggregates by interacting with p62, while amyloid fibrils evade clearance due to their non-deformable structure.

Combinatorial selective ER-phagy remodels the ER during neurogenesis

The paper quantifies ER proteome remodeling during neurogenesis using ER-phagy receptors and identifies receptor-specific ER protein clearance mechanisms.

In situ structural analysis reveals membrane shape transitions during autophagosome formation

This study uses cryo-electron tomography to analyze autophagosome formation in yeast, revealing membrane shape transitions and interactions during biogenesis.

In cell architecture of the nuclear pore complex and snapshots of its turnover

The paper uses structural biology and yeast genetics to study NPC architecture and turnover in yeast cells, revealing new insights into mRNA export and autophagy mechanisms.

A selective autophagy pathway for phase separated endocytic protein deposits

The paper identifies Ede1 as a selective autophagy receptor for endocytic protein condensates, showing its role in phase separation and autophagic degradation.