Author

A. Jen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. J. Coon· 3 shared K. A. Overmyer· 3 shared E. Shishkova· 2 shared A. Bieber· 1 shared A. D. Attie· 1 shared A. Galmozzi· 1 shared A. Jaitovich· 1 shared B. A. Schulman· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

J. J. Coon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Substrate-directed control of N-glycosylation in the endoplasmic reticulum calibrates signal reception at the cell-surface

R. Rohatgi, M. Ma, R. Dubey, A. Jen, G. V. Pusapati, E. Shishkova, K. A. Overmyer, V. Cormier-Daire, L. Aravind, J. J. Coon

The paper identifies an ER pathway that regulates N-glycosylation by modulating OST-A activity, impacting cell-surface signaling and tissue development.

bioRxiv · Apr 25, 2024 · PreprintCell Biology

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

F. Kraus, Y. He, S. Swarup, K. A. Overmyer, J. Brenner, C. Capitanio, A. Bieber, A. Jen, N. M. Nightingale, B. J. Anderson, C. Lee, J. A. Paulo, I. R. Smith, J. M. Plitzko, S. P. Gygi, , J. W. Harper

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

bioRxiv · Mar 26, 2024Cell Biology

Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

D. J. Duerre, J. K. Hansen, S. John, A. Jen, N. Carrillo, H. Bui, Y. Bao, M. Fabregat, K. Overmyer, E. Shishkova, M. P. Keller, R. A. Anderson, V. L. Cryns, A. D. Attie, J. Coon, , A. Galmozzi

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

bioRxiv · Nov 28, 2023 · PreprintCell Biology

A role for cytoglobin in regulating intracellular hydrogen peroxide and redox signals in the vasculature

C. Mathai, F. L. Jourd'heuil, L. G. C. Pham, K. Gilliard, J. Balnis, A. Jen, K. A. Overmyer, J. J. Coon, A. Jaitovich, B. Boivin, D. Jourd'heuil

This study shows cytoglobin regulates intracellular hydrogen peroxide and redox signals by reducing hyperoxidation of peroxiredoxins and facilitating Hyper7 reduction, independent of heme-based hydrogen peroxide reactions.

bioRxiv · Mar 31, 2023 · PreprintBiochemistry