Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
F. Kraus, Y. He, S. Swarup, K. A. Overmyer, J. Brenner, C. Capitanio, A. Bieber, A. Jen, N. M. Nightingale, B. J. Anderson, C. Lee, J. A. Paulo, I. R. Smith, J. M. Plitzko, S. P. Gygi, , J. W. Harper
This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.
bioRxiv · Mar 26, 2024Cell Biology
F. Adolf, J. Du, E. A. Goodall, R. M. Walsh, S. rawson, S. von Gronaua, J. W. Harper, J. Hanna, B. A. Schulman
The paper uses cryo-EM to visualize the assembly of the human 20S proteasome, revealing how chaperones and propeptides guide subunit incorporation and proteasome activation.
bioRxiv · Jan 27, 2024Biochemistry
M. E. Watts, R. M. Giadone, A. Ordureau, K. M. Holton, J. W. Harper, L. L. Rubin
The paper uses ER stressors in ALS patient-derived motor neurons to identify druggable targets that protect against degeneration.
bioRxiv · Nov 16, 2023Cell Biology
K. L. Hickey, S. Swarup, I. R. Smith, J. C. Paoli, J. A. Paulo, J. W. Harper
The paper identifies YIPF3 and YIPF4 as membrane receptors for Golgiphagy during nutrient stress and shows their role in autophagic degradation of Golgi proteins.
bioRxiv · Dec 6, 2022Cell Biology
F. Kraus, E. A. Goodall, I. R. Smith, Y. Jiang, J. C. Paoli, F. Adolf, J. Zhang, J. A. Paulo, B. A. Schulman, J. W. Harper
This study shows FBXO7 is not required for PINK1/Parkin-dependent mitophagy in HeLa and iNeuron cells, as its absence does not impair key mitophagy processes.
bioRxiv · Nov 2, 2022Cell Biology
S. Boland, S. Swarup, Y. A. Ambaw, R. C. Richards, A. W. Fischer, S. Singh, G. Aggarwal, S. Spina, A. L. Nana, L. T. Grinberg, W. W. Seeley, M. A. Surma, C. Klose, J. A. Paulo, A. D. Nguyen, , R. V. Farese
This study shows that progranulin deficiency reduces bis(monoacylglycero)phosphate levels, leading to gangliosidosis and neurodegeneration.
bioRxiv · Sep 30, 2021Cell Biology
V. V. Eapen, S. Swarup, M. J. Hoyer, J. A. Paulo, J. W. Harper
This study identifies TAX1BP1 as essential for lysophagy by using proteomics and flux reporters to show its role in damaged lysosome turnover.
bioRxiv · Jul 19, 2021Cell Biology
D. M. Garshott, H. An, E. Sundaramoorthy, M. Leonard, A. Vicary, J. W. Harper, E. J. Bennett
This study identifies a new ribosome quality control pathway, iRQC, that responds to ribosome collisions during translation initiation by ubiquitylating and degrading 40S ribosomal proteins.
bioRxiv · Apr 20, 2021Cell Biology
P. J. Wrighton, A. Shwartz, J.-M. Heo, E. D. Quenzer, K. A. LaBella, J. W. Harper, W. Goessling
This study uses intravital imaging in zebrafish to show that fasting and hypoxia induce mitophagy, with bnip3 as the key regulator in muscle.
bioRxiv · Mar 26, 2020Cell Biology
A. A. Kendrick, W. B. Redwine, P. T. Tran, L. Pontano Vaites, M. Dzieciatkowska, J. W. Harper, S. L. Reck-Peterson
This study identifies HOOK3 as a scaffold that links cytoplasmic dynein and KIF1C, enabling bidirectional transport by coupling opposite-polarity microtubule-based motors.
bioRxiv · Dec 31, 2018Cell Biology