Author

I. Smyrnias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

D. I. Bromage· 2 shared G. Sawyer· 2 shared X. Zhang· 2 shared A. D. Hafstad· 1 shared A. Ivetic· 1 shared A. M. Shah· 1 shared A. Muthukumar· 1 shared A. Ruggieri· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

D. I. Bromage

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Activation of the mitochondrial unfolded protein response regulates the formation of stress granules

M. Lopez-Nieto Jordana, Z. Sun, E. Relton, R. Safakli, B. D. Freibaum, J. P. Taylor, A. Ruggieri, I. Smyrnias, N. Locker

The paper shows that the mitochondrial unfolded protein response (UPRmt) interacts with stress granules (SGs) to regulate cellular stress responses and mitochondrial homeostasis.

bioRxiv · Oct 26, 2023 · PreprintCell Biology

NRF2 activation in the heart induces glucose metabolic reprogramming and mediates cardioprotection via upregulation of the pentose phosphate pathway.

A. Zoccarato, I. Smyrnias, C. M. Reumiller, A. D. Hafstad, M. Chong, D. A. Richards, C. X. Santos, A. Visnagri, D. I. Bromage, X. Zhang, G. Sawyer, R. Thompson, A. M. Shah

This study shows NRF2 activation in the heart increases the pentose phosphate pathway, protects against cardiac stress by reducing DNA damage and improving function.

bioRxiv · May 12, 2023 · PreprintPhysiology

Nrf2 attenuates the innate immune response after experimental myocardial infarction

D. I. Bromage, S. C. Trevelin, J. Huntington, V. Yang, A. Muthukumar, S. Mackie, G. Sawyer, X. Zhang, C. Santos, N. Safinia, I. Smyrnias, M. Giacca, A. Ivetic, A. Shah

This study shows that Nrf2 reduces inflammation after myocardial infarction by suppressing pro-inflammatory cytokines and chemokines in mice.

bioRxiv · Jan 10, 2022Immunology