Author

C. Santos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Immunology· 2 Microbiology· 2 Biophysics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. Villanueva· 2 shared C. Luongo· 2 shared D. Alvarez-Villanueva· 2 shared H.-S. Park· 2 shared L. Yang· 2 shared P. Lusso· 2 shared P. Zhang· 2 shared R. salazar· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Villanueva

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters

X. Liu, H.-S. Park, Y. Matsuoka, C. Santos, L. Yang, C. Luongo, I. Moore, R. Johnson, N. Garza, P. Zhang, P. Lusso, S. Best, U. Buchholz, C. Le Nouën

This study compares two live-attenuated vaccines in hamsters, showing that B/HPIV3/S-6P induces stronger immune responses and better protection against SARS-CoV-2 variants than B/HPIV3/S-2P.

PLOS Pathogens · Jun 23, 2023Peer-reviewedMicrobiology

IKK1 kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

L. Espinosa, I. Pecharroman Ruiz, L. Sole, D. Alvarez-Villanueva, T. Lobo, J. Alonso, j. Bertran, E. Sabido, E. Borras, V. Garcia-Hernandez, M. garrido, J. Seoane, A. Bigas, A. Villanueva, M. Martinez-Iniesta, , R. salazar

This study identifies IKK1's role in coordinating BRD4 and JAK/STAT signaling to resist DNA damage-based therapy in colorectal cancer.

bioRxiv · Jun 13, 2023 · PreprintCancer Biology

CryoET shows cofilactin filaments inside the microtubule lumen

C. Santos, S. L. Rogers, A. P. Carter

The paper uses cryoET to identify cofilactin filaments inside microtubule lumens in Drosophila cells and shows their association with cofilin activation.

bioRxiv · Mar 31, 2023 · PreprintCell Biology

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

M. H. Dias, A. Friskes, S. Wang, J. M. H. Fernandes Neto, F. v. Gemert, S. Mourragui, H. J. Kuiken, S. Mainardi, D. Alvarez-Villanueva, C. Lieftink, B. Morris, A. Dekker, E. v. Dijk, C. Papagianni, M. S. da Silva, , R. Bernards

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

bioRxiv · Feb 6, 2023Cancer Biology

Plant signals anticipate the induction of the type III secretion system in Pseudomonas syringae pv. actinidiae facilitating efficient temperature-dependent effector translocation

M. R. Puttilli, D. Danzi, C. Correia, J. Brandi, D. Cecconi, M. Manfredi, E. Marengo, C. Santos, F. Spinelli, A. Polverari, E. VANDELLE

The paper shows plant signals and temperature regulate the timing of bacterial virulence in Pseudomonas syringae, influencing effector translocation and disease outcome.

bioRxiv · Jun 1, 2022Microbiology

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques

C. Le Nouen, C. E. Nelson, X. Liu, H.-S. Park, Y. Matsuoka, C. Luongo, C. Santos, L. Yang, R. Herbert, A. Castens, I. N. Moore, T. Wilder-Kofie, R. Moore, A. Walker, P. Zhang, , U. J. Buchholz

This study evaluates an intranasal parainfluenza virus-vectored SARS-CoV-2 vaccine in macaques, showing it induces mucosal and systemic immunity and protects against viral challenge.

bioRxiv · May 21, 2022Immunology

Nrf2 attenuates the innate immune response after experimental myocardial infarction

D. I. Bromage, S. C. Trevelin, J. Huntington, V. Yang, A. Muthukumar, S. Mackie, G. Sawyer, X. Zhang, C. Santos, N. Safinia, I. Smyrnias, M. Giacca, A. Ivetic, A. Shah

This study shows that Nrf2 reduces inflammation after myocardial infarction by suppressing pro-inflammatory cytokines and chemokines in mice.

bioRxiv · Jan 10, 2022Immunology

Theoretical causes of the Brazilian P.1 and P.2 lineages of the SARS-CoV-2 virus through molecular dynamics

M. D. Lima de Oliveira, K. M. Teixeira de Oliveira, J. Nunes da Silva, C. Santos, J. Bessa, R. de Freitas

This paper uses molecular dynamics simulations to analyze structural changes in the ACE2-RBD complex and neutralizing antibody interactions in the P.1 and Delta variants of SARS-CoV-2, finding increased stability in P.1 and reduced antibody recognition.

bioRxiv · Apr 9, 2021 · PreprintBiophysics

Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay

F. Cairrao, C. Santos, A. Le-Thomas, S. Marsters, A. Ashkenazi, P. Domingos

The paper identifies Pumilio's role in protecting Xbp1spliced mRNA from RIDD by Ire1-mediated phosphorylation in Drosophila.

bioRxiv · Feb 8, 2021Cell Biology

Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients

L. Haupt, A. Maus, M. Tiburcy, S. Koehne, W. Maurer, R. Tappu, J. Haas, Y. Li, A. Sasse, C. Santos, R. Dressel, L. Wojnowski, G. Bunt, A. M. Shah, B. Meder, , K. Streckfuss-Bömeke

This study develops a human iPSC-CM model of DOX-induced cardiac dysfunction in B-cell lymphoma patients with high-dose DOX treatment, showing increased susceptibility to DOX toxicity and impaired mechanical function.

bioRxiv · Apr 15, 2020Cell Biology

Metabolomic profiling revels systemic signatures of premature aging induced by Hutchinson-Gilford Progeria Syndrome

G. Monnerat, G. Evaristo, J. Evaristo, C. Santos, G. Reis, L. Maciel, V. Carvalho, F. C. Nogueira, G. B. Domont, A. C. Campos de Carvalho

This study identifies metabolic biomarkers of premature aging in HGPS patients through metabolomic profiling and multivariate analysis.

bioRxiv · Feb 19, 2019Pathology