Genomic and experimental evidence that alternate transcription initiation of the Anaplastic Lymphoma Kinase (ALK) kinase domain does not predict single agent sensitivity to ALK inhibitors.
H. Inam, I. Sokirniy, Y. Rao, A. Shah, F. Naeemikia, E. O'Brien, C. Dong, D. M. McCandlish, J. R. Pritchard
The paper reanalyzes ALKATI's role in melanoma using genomic and experimental methods, finding it does not predict single-agent ALK inhibitor sensitivity.
bioRxiv · Jun 17, 2021 · PreprintBioengineering