Author

B. Bornhauser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J.-P. Bourquin· 2 shared A. Cavalli· 1 shared A. E. Kulozik· 1 shared A. G. Volk· 1 shared A. Hierlemann· 1 shared A. J. Arribas· 1 shared A. Kaestli· 1 shared A. Lupia· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

J.-P. Bourquin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Role of Stem-Like Cells in Chemotherapy Resistance and Relapse in pediatric T Cell Acute Lymphoblastic Leukemia

J. Costea, K. K. Rauwolf, P. Zafferani, T. Rausch, A. Mathioudaki, J. B. Zaugg, M. Schrappe, C. Eckert, G. Escherich, J.-P. Bourquin, B. Bornhauser, A. E. Kulozik, J. O. Korbel

This study identifies treatment-resistant stem-like T-ALL cells that expand during relapse using single-cell RNA sequencing of pediatric T-ALL patient samples.

bioRxiv · Jun 24, 2024Cancer Biology

A first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity in hematological cancers

F. Spriano, G. Sartori, L. Barnabei, A. J. Arribas, M. Guala, A. M. Carrasco del Amor, M. R. Tomasso, C. Tarantelli, L. Cascione, G. Golino, M. E. Riveiro, R. Bortolozzi, A. Lupia, F. Paduano, S. Huguet, , E. Gaudio

This paper develops EG-011, a first-in-class WASp activator with anti-tumor activity in hematological cancers, including resistant models.

bioRxiv · Nov 25, 2022 · PreprintCancer Biology

Microphysiological Drug-Testing Platform For Identifying Responses To Prodrug Treatment In Primary Leukemia

F. Gokce, A. Kaestli, C. Lohasz, M. de Geus, H. M. Kaltenbach, K. Renggli, B. Bornhauser, A. Hierlemann, M. M. Modena

The paper develops a microphysiological platform to test prodrug responses in leukemia samples, identifying sample-specific sensitivities to ifosfamide.

bioRxiv · Apr 6, 2022Bioengineering

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptionalprogram in T cell leukemia

P. Ntziachristos, K. Arcipowski, Q. Jin, C. A. Martinez, Y. Zhu, B. T. Gutierrez Diaz, K. Wang, M. Johnson, A. G. Volk, F. Wang, J. wu, H. Wang, I. Sokirniy, P. Thomas, Y. A. Goo, , J. D Crispino

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.

bioRxiv · Jan 16, 2018Cancer Biology