Author

P. Ntziachristos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. van Vlierberghe· 2 shared Y. Zhu· 2 shared A. G. Volk· 1 shared A. Kloetgen· 1 shared A. strikoudis· 1 shared A. Tsirigos· 1 shared B. Accordi· 1 shared B. Bornhauser· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

P. van Vlierberghe

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2 papers

Recent·Most cited

Dynamic 3D chromosomal landscapes in acute leukemia

A. Kloetgen, P. Thandapani, P. Ntziachristos, Y. Ghebrechristos, S. Nomikou, C. Lazaris, X. Chen, H. Hu, S. Bakogianni, J. Wang, Y. Fu, F. Boccalatte, H. Zhong, E. Paietta, T. Trimarchi, , A. Tsirigos

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.

bioRxiv · Aug 4, 2019Cancer Biology

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptionalprogram in T cell leukemia

P. Ntziachristos, K. Arcipowski, Q. Jin, C. A. Martinez, Y. Zhu, B. T. Gutierrez Diaz, K. Wang, M. Johnson, A. G. Volk, F. Wang, J. wu, H. Wang, I. Sokirniy, P. Thomas, Y. A. Goo, , J. D Crispino

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.

bioRxiv · Jan 16, 2018Cancer Biology